CBD, the non-psychoactive substance in cannabis, is currently the subject of a great deal of research. This research often focuses on the brain, in particular neuroplasticity and neurogenesis. While the results cannot precisely determine its effects on these processes, its involvement in certain phenomena cannot be denied. To find out more, here's how CBD affects neuroplasticity and neuronal regeneration.
Impact of CBD on neuroplasticity
Neuroplasticity refers to the brain's ability to modify existing neural connections. This means adapting and renewing oneself in the face of the environment. This is an important biological process which has an impact on certain aspects: memory, learning and recovery.
It's important to know that CBD can act in different ways to help modulate this process. That's why it's important to choose the right best cannabidiol oils in such cases.
Regulation of neurotransmitters
Neurotransmitters are essential elements in the regulation of mechanisms such as anxiety. According to a study on the therapeutic potential of CBD, it is believed to have effects on the receptors of these neurotransmitters (1).
The latter play a key role in the modulation of synaptic plasticity. The latter is the ability of synapses to optimize or alter transmission capacity according to neuronal activity. Hence the importance of CBD's involvement with neurotransmitters.
Anti-inflammatory and neuroprotective properties
The impact of CBD on neuroplasticity is also due to its anti-inflammatory and neuroprotective properties. A study on cannabidiol actually demonstrated that CBD inhibits adenosine reuptake, producing an anti-inflammatory and neuroprotective effect (2).
CBD therefore reduces neuroinflammation and helps to preserve neurons and synapses from damage. This in turn has a positive effect on new neuron connections.
Regulation of gene expression and intracellular signalling
Cannabidiol may also be involved in these two important mechanisms. This, in turn, modulates certain processes impacting neuroplasticity. According to a thesis on the medical uses of cannabidiol, it has been shown that CBD impacts the endocannabinoid system (3). This will have an effect, for example, on intracellular signalling and certain processes involving neurotransmitters.
Regulation of gliogenesis
Gliogenesis, the process of producing new glial cells, is essential for neuronal support. These cells create an environment conducive to neuroplasticity. Today, studies on mice have revealed that the use of CBD following a stroke stimulated the production of glial cells.
Impact of CBD on neuronal regeneration
Neural regeneration is a process that takes place during all phases of a person's brain life. Indeed, this process is fundamental to the brain's ability to function properly. It is also an important process for recover from neuronal damage.
Current research on CBD has focused on the substance's influence on neurogenesis. While this research has not yet reached a conclusive conclusion, it does reveal the following the impact of cannabidiol in this aspect of the brain.
Stimulating neurogenesis
Neurogenesis has a major impact on many aspects of learning, memory, mood and recovery from brain damage. Visit CBD may contribute to neurogenesis thanks to its neuroprotective properties.
In fact, according to a study conducted on cannabidiol, the following effects were observed neuroprotective effects of CBD. This has led to an influence on hippocampal neurogenesis. CBD thus helps to form new neurons, which can help in cases such as depression.
Reduce anxiety and depression
Cannabidiol is favoured mainly for its virtues in anxiety and stress management. One way to reduce anxiety is to stimulate neuronal regeneration dans l’hippocampe. Cela permet alors une amélioration de l’humeur et une meilleure gestion du stress.
Une étude sur le potentiel thérapeutique du CBD a effectivement démontré qu’une administration chronique systémique de CBD entraîne une neurogénèse hippocampique.
Anti-inflammatory action
Le processus de neurogenèse peut être influencé par certains facteurs tels que l’inflammation chronique. Le CBD peut ainsi avoir un impact sur ce processus grâce à ses propriétés inflammatoires.
En effet, comme on l’a mentionné précédemment, le cannabidiol a des actions anti-inflammatoires. Cela lui permet ainsi d’atténuer ou de réduire une inflammation chronique. Ce qui permet d’apporter des conditions favorables pour la régénération neuronale.
Impact of CBD on neuroplasticity and neuronal regeneration: therapeutic applications
La capacité du cannabidiol à s’impliquer dans la neuroplasticité et la régénération neuronale permet de traiter divers troubles. Il s’agit de troubles neurologiques et neuropsychiatriques.
Epilepsy
Il a été vu que le cannabidiol est une substance qui dispose de certaines propriétés anti-inflammatoires et neuroprotectrices. Il a aussi la capacité de réguler les neurotransmetteurs. Cela permet alors d’atténuer les crises liées à l’épilepsie et de stimuler la neurogenèse et la neuroplasticité.
Autism spectrum disorders (ASD)
Les TSA sont généralement liés à des dommages au niveau de la plasticité cérébrale et des connexions des neurones. Certaines études démontrent que le cannabidiol aurait la faculté d’améliorer l’état (comportements et communication) des personnes souffrant du trouble.
Alzheimer's disease
Ceci est un trouble neurodégénératif qui se manifeste par des dommages progressifs des neurones et une réduction de la neuroplasticité. Le CBD est un composant qui est aujourd’hui au cœur des recherches pour cette maladie.
S’il n’y pas encore de résultats probants, certaines études ont permis de mettre en avant la capacité du CBD à freiner le développement de la maladie. La substance permet également d’améliorer certaines fonctions (cognitives et mémorielles) . Cela est dû notamment aux différentes propriétés de cette solution naturelle : neuroprotectrices, anti-inflammatoires, etc.
En bref, on peut dire que le CBD a effectivement un impact sur la neuroplasticité et la régénération neuronale. Ces effets sont surtout le résultat des propriétés bien connues de cette substance naturelle (anti-inflammatoires, neuroprotectrices, etc.). C’est pourquoi, aujourd’hui, ce composant du cannabis est au centre de plusieurs recherches sur les maladies neurologiques.
- 1.https://dumas.ccsd.cnrs.fr/dumas-04207453v1/file/THANGUY_Pauline.pdf
- 2.https://dumas.ccsd.cnrs.fr/dumas-03555403v1/file/CBD-%20th%C3%A8se.pdf
- 3.https://dumas.ccsd.cnrs.fr/dumas-03934518
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